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NIBIB Biomedical Imaging

Implantable sensors are helping scientists improve injury recovery

Implantable sensors are helping scientists improve injury recovery NIBIB in the News clehmann Wed, 01/15/2025 - 11:49
Tiny implantable sensors are helping University of Oregon researchers optimize the process of recovery from severe bone injuries. In a new study, they use the technology to show that a resistance-training rehabilitation program can significantly improve femur injuries in rats in just eight weeks.

Source: University of Oregon Phil and Penny Knight Campus for Accelerating Scientific Impact
President Biden honors nearly 400 federally funded early-career scientists

President Biden honors nearly 400 federally funded early-career scientists NIBIB in the News cooperca2 Wed, 01/15/2025 - 08:36
Five NIBIB grantees received the Presidential Early Career Award for Scientists and Engineers: Ambika Goel Bajpayee, Northeastern University; Samira Kiani, University of Pittsburgh; Kanaka Rajan, Harvard Medical School; Parisa Rashidi, University of Florida; and William Renninger, University of Rochester. The award is the highest honor bestowed by the U.S. Government on outstanding scientists and engineers at the early career stage.
Seeing eye to eye: building a cost-effective tool to visualize cancer

Seeing eye to eye: building a cost-effective tool to visualize cancer Science Highlights kolsen Wed, 01/08/2025 - 10:16
In an effort to greatly expand accessibility, this compact fluorescence-guided surgery system, evaluated in mice, is crafted from cost-effective and off-the-shelf components.
From Sci-Fi Fears to Medical Miracles

From Sci-Fi Fears to Medical Miracles NIBIB in the News raymond.macdougall Fri, 01/10/2025 - 14:10
AI, specifically, machine learning, can help improve the quality of these MRI images, making it easier for doctors to diagnose patients. Machine learning involves training AI on a lot of data to recognize trends and make predictions on new data it receives. Source: Curious Science Writers
Major breakthrough for ‘smart cell’ design

Major breakthrough for ‘smart cell’ design NIBIB in the News clehmann Mon, 01/06/2025 - 10:09
Rice University bioengineers have developed a new construction kit for building custom sense-and-respond circuits in human cells. The research, published in the journal Science, represents a major breakthrough in the field of synthetic biology that could revolutionize therapies for complex conditions like autoimmune disease and cancer. Source: Rice University News & Media Relations
Enter the Physicianeers - How They Will Transform Healthcare

Enter the Physicianeers - How They Will Transform Healthcare NIBIB in the News cooperca2 Mon, 01/13/2025 - 09:57
Former NIBIB Director Dr. Roderic I. Pettigrew's viewpoint article in JAMA discusses the integration of medicine and engineering to transform how disease is prevented, diagnosed, and treated. JAMA
Gene editing tool reduces Alzheimer’s plaque precursor in mice

Gene editing tool reduces Alzheimer’s plaque precursor in mice NIBIB in the News clehmann Mon, 12/30/2024 - 09:47
A new gene editing tool that helps cellular machinery skip parts of genes responsible for diseases has been applied to reduce the formation of amyloid-beta plaque precursors in a mouse model of Alzheimer’s disease, researchers at the University of Illinois Urbana-Champaign report. Source: University of Illinois Urbana-Champaign News Bureau
Engineering a smile

Engineering a smile Science Highlights jgriffin Thu, 12/19/2024 - 13:00
With the help of some of nature’s best engineers, NIBIB-funded researchers have developed technology to regrow damaged facial nerves.
Need a research hypothesis? Ask AI.

Need a research hypothesis? Ask AI. NIBIB in the News clehmann Mon, 12/23/2024 - 09:24
Massachusetts Institute of Technology (MIT) engineers developed AI frameworks to identify evidence-driven hypotheses that could advance biologically inspired materials. Source: MIT News
Building a multilayered drug delivery system that’s activated by ultrasound

Building a multilayered drug delivery system that’s activated by ultrasound Science Highlights clehmann Thu, 12/19/2024 - 09:46
Releasing a drug selectively in specific locations in the body, including the brain, has been challenging. Researchers at the University of Utah have tackled the problem by designing ultrasound-sensitive nanoparticles that release a drug at the targeted site when activated by focused ultrasound.
NIH announces awards to advance tech for HIV viral load detection

NIH announces awards to advance tech for HIV viral load detection Science Highlights raymond.macdougall Mon, 12/16/2024 - 15:58
NIH has awarded more than $4 million in funds and support services to three diagnostic technology developers as part of RADx ® Tech’s Advanced Platforms for HIV Viral Load Monitoring program.
Astronaut-on-a-chip: modeling the effects of radiation exposure using multi-organ tissue chips

Astronaut-on-a-chip: modeling the effects of radiation exposure using multi-organ tissue chips Science Highlights nkalkunte Tue, 12/17/2024 - 11:17
Researchers use multiorgan tissue chips to study the impacts of space radiation on human physiology to support the astronauts of tomorrow.
Innovative tissue engineering: Boston University's ESCAPE method explained

Innovative tissue engineering: Boston University's ESCAPE method explained NIBIB in the News clehmann Thu, 12/12/2024 - 09:02
Researchers at Boston University and the Wyss Institute at Harvard University have invented a new approach to biologically engineering tissue structures called ESCAPE (engineered sacrificial capillary pumps for evacuation). Source: Wyss Institute/Harvard University News
Rockville Native Parinaz Fathi Makes 2025 Forbes 30 Under 30 List

Rockville Native Parinaz Fathi Makes 2025 Forbes 30 Under 30 List NIBIB in the News jgriffin Thu, 12/12/2024 - 13:09
Parinaz Fathi, a Rockville native who graduated from the University of Maryland in 2015 before moving on to the University of Illinois Urbana-Champaign to complete her Ph.D.in 2020, has been named tot he 2025 Forbes 30 Under 30 List in the Science category. Source: The MoCo Show
Trio of Terps Named to Forbes’ 30 Under 30 Lists

Trio of Terps Named to Forbes’ 30 Under 30 Lists NIBIB in the News jgriffin Thu, 12/12/2024 - 13:03
Parinaz Fathi ’15 (mechanical engineering) was featured on the Science list. She developed VIPER (Vital Injury Protein Evaluation for Recovery), a powerful tool that can predict survival in cases of traumatic injury. Source: Maryland Today
New Cornell tech to evaluate anemia to be used across India

New Cornell tech to evaluate anemia to be used across India NIBIB in the News jgriffin Wed, 12/04/2024 - 15:48
AnemiaPhone, a technology developed by a multidisciplinary team of Cornell researchers to accurately, quickly and cheaply assess iron deficiency, has been transferred to the Indian Council of Medical Research of the government of India for integration into its programs for anemia, women’s health, and maternal and child health throughout the country. Source: Cornell Chronicle
Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry NIBIB in the News clehmann Mon, 12/02/2024 - 13:07
A tiny, four-fingered “hand” folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, University of Illinois Urbana-Champaign researchers report. Source: University of Illinois Urbana-Champaign News Bureau
Researchers develop clinically validated, wearable ultrasound patch for continuous blood pressure monitoring

Researchers develop clinically validated, wearable ultrasound patch for continuous blood pressure monitoring NIBIB in the News clehmann Tue, 11/26/2024 - 10:48
A team of researchers at the University of California San Diego has developed a new and improved wearable ultrasound patch for continuous and noninvasive blood pressure monitoring. Their work marks a major milestone, as the device is the first wearable ultrasound blood pressure sensor to undergo rigorous and comprehensive clinical validation on over 100 patients. Source: UC San Diego.
Switching off drug-resistant cancer

Switching off drug-resistant cancer Science Highlights jgriffin Tue, 11/19/2024 - 09:56
With their eclectic mix of mutations, tumors often survive drug treatment. In a new study, researchers found a way to use cancer’s evolutionary potential against it, destroying drug-resistant tumors in animals.
Researchers shed light on skin tone bias in breast cancer imaging

Researchers shed light on skin tone bias in breast cancer imaging NIBIB in the News clehmann Fri, 11/15/2024 - 10:59
A team of researchers from Johns Hopkins University recently investigated how skin tone affects the visibility of breast cancer targets in photoacoustic imaging. They found that that a new imaging technique reduces skin tone bias, improving visibility across diverse skin tones. Source: The International Society for Optics and Photonics.
Researchers develop minimally invasive neural interface in revolutionary study

Researchers develop minimally invasive neural interface in revolutionary study NIBIB in the News clehmann Thu, 11/14/2024 - 16:21
A team of researchers led by Rice University’s Jacob Robinson and the University of Texas Medical Branch’s Peter Kan with NIBIB funding have developed a technique for diagnosing, managing and treating neurological disorders with minimal surgical risks. Source: Rice University News.
Researchers develop robotic sensory cilia that monitor internal biomarkers to detect and assess airway diseases

Researchers develop robotic sensory cilia that monitor internal biomarkers to detect and assess airway diseases NIBIB in the News clehmann Fri, 11/08/2024 - 09:07
A team of researchers at Vanderbilt University has developed a system of artificial cilia capable of monitoring mucus conditions in human airways to better detect infection, airway obstruction, or the severity of diseases like Cystic Fibrosis (CF), Chronic Obstructive Pulmonary Diseases (COPD) and lung cancer. The lead researcher was funded by an NIH/NIBIB Trailblazer Award. Source: Vanderbilt School of Engineering
NIBIB initiative expands the biomedical engineering, imaging, and technology acceleration aspirations of HBCUs

NIBIB initiative expands the biomedical engineering, imaging, and technology acceleration aspirations of HBCUs Science Highlights raymond.macdougall Wed, 10/30/2024 - 15:35
NIBIB has designed an initiative called Enhancing Biomedical Engineering, Imaging, and Technology Acceleration (eBEITA) at HBCUs. Recently, NIBIB made its first round of eBEITA grants to two HBCUs.
New liquid biopsy method offers avenue to quick, affordable cancer diagnosis

New liquid biopsy method offers avenue to quick, affordable cancer diagnosis NIBIB in the News clehmann Fri, 11/01/2024 - 16:00
In a study published in Small, researchers at the University of Rochester outline a new method for using ultrathin membranes to easily identify extracellular vesicles for rapid liquid biopsies. The method, called catch and display for liquid biopsy (CAD-LB), holds promise for diagnosing cancer quickly and affordably, and assessing the progress of therapies used to treat diseases. Source: University of Rochester News
NIH announces prize winners in year-long challenge to develop fetal diagnostic and monitoring technologies

NIH announces prize winners in year-long challenge to develop fetal diagnostic and monitoring technologies Press Releases raymond.macdougall Wed, 10/30/2024 - 16:45
NIH has announced winners of the RADx® Tech Fetal Monitoring Challenge, a $2 million prize competition to speed development of innovative medical technologies for fetal health diagnosis, detection and monitoring.
Unraveling colorectal cancer metastasis: Study provides new insights and potential therapeutic opportunities

Unraveling colorectal cancer metastasis: Study provides new insights and potential therapeutic opportunities NIBIB in the News clehmann Wed, 10/30/2024 - 16:43
Metastasis remains the primary challenge to reducing cancer deaths worldwide. Now, a study by Memorial Sloan Kettering, published in Nature is providing unique insights into metastasis that researchers say point to new therapeutic opportunities. Source: Memorial Sloan Kettering Cancer Center News
Microgrippers for myriad miniature biopsies

Microgrippers for myriad miniature biopsies Science Highlights kolsen Fri, 10/25/2024 - 10:41
Researchers are developing preclinical microgrippers that could be deployed throughout the upper urinary tract to grab tiny pieces of tissue and facilitate early detection of disease.
New liquid biopsy method offers avenue to quick, affordable cancer diagnosis

New liquid biopsy method offers avenue to quick, affordable cancer diagnosis NIBIB in the News clehmann Tue, 10/29/2024 - 09:04
In a study published in Small, researchers at the University of Rochester outline a new method for using ultrathin membranes to easily identify extracellular vesicles for rapid liquid biopsies. The method, called catch and display for liquid biopsy (CAD-LB), holds promise for diagnosing cancer quickly and affordably, and assessing the progress of therapies used to treat diseases. Source: University of Rochester News Center
Immunotherapy blocks scarring, improves heart function in mice with heart failure

Immunotherapy blocks scarring, improves heart function in mice with heart failure NIBIB in the News clehmann Mon, 10/28/2024 - 08:54
Researchers at Washington University Medicine have reduced scar formation and improved heart function in mouse models of heart failure using a monoclonal antibody treatment. The antibody that reduces inflammation could serve as cardio-immunotherapy for heart failure patients. Source: WashU Medicine
University of Houston engineers unveil AI model for predicting, controlling pandemic spread

University of Houston engineers unveil AI model for predicting, controlling pandemic spread NIBIB in the News clehmann Mon, 10/28/2024 - 08:22
A team of engineers at the University of Houston has published a study in the journal Nature on how international air travel has influenced the spread of COVID-19 around the world. By using a newly developed AI tool, the team identified hotspots of infection linked to air traffic, pinpointing key areas that significantly contribute to disease transmission. Source: University of Houston Newsroom
A new hydrogel semiconductor represents a breakthrough for tissue-interfaced bioelectronics

A new hydrogel semiconductor represents a breakthrough for tissue-interfaced bioelectronics NIBIB in the News clehmann Thu, 10/24/2024 - 15:04
The University of Chicago Pritzker School of Molecular Engineering (PME) has solved a challenge that has long stymied researchers, reimagining the process of creating hydrogels to build a powerful semiconductor in hydrogel form that can be used to create better brain-machine interfaces, biosensors, and pacemakers. Source: UChicago Pritzker School of Molecular Engineering News.
Forming an interdisciplinary future

Forming an interdisciplinary future Science Highlights jgriffin Thu, 10/17/2024 - 14:47
NIBIB bioengineer Kaitlyn Sadtler has flourished as a leader of many impactful, interdisciplinary studies. For her role in shaping the future of medical research, TIME magazine has named Kaitlyn Sadtler to the TIME100 Next 2024 List.
Researchers develop 3D atlas of the developing mammalian brain

Researchers develop 3D atlas of the developing mammalian brain NIBIB in the News clehmann Mon, 10/21/2024 - 16:02
A team of researchers at Penn State College of Medicine and collaborators from five institutes have developed a new 3D atlas of developing mice brains using advanced imaging and microscopy techniques. The new high-resolution maps of the mouse brain will help advance the understanding of brain development and the study of neurodevelopment disorders.

Source: Penn State Research News
Custom alterations: mending genes for long-lasting effects

Custom alterations: mending genes for long-lasting effects Science Highlights kolsen Thu, 10/03/2024 - 15:25
NIBIB-funded researchers are working to bring in vivo gene editing to the fore. Through rational engineering of lipid nanoparticles, this collaborative team developed a way to effectively target specific organs in the body to precisely deliver therapeutic cargo, including gene-editing molecules. Their research demonstrated that a one-time treatment with their nanoparticles resulted in durable gene editing in mouse lungs for nearly two years. Further, their technique showed promise in correcting a mutation present in a currently untreatable form of cystic fibrosis in several models of the disease.
A new method makes high-resolution imaging more accessible

A new method makes high-resolution imaging more accessible NIBIB in the News clehmann Tue, 10/15/2024 - 08:45
Labs that can’t afford expensive super-resolution microscopes could use a new expansion technique to image nanoscale structures inside cells. Source: MIT News
Optimizing Inhibitors That Fight Antibiotic Resistance

Optimizing Inhibitors That Fight Antibiotic Resistance NIBIB in the News clehmann Fri, 10/11/2024 - 07:31
As strains of pathogens resistant to frontline antibiotics become more common worldwide, clinicians are more often turning to combination treatments that degrade this resistance as a first treatment option.

Researchers from Duke University have discovered the mechanism behind why some antibiotic-resistant pathogens haven't adapted to the combination treatments—the bacteria’s level of “selfishness.” The insight provides guidance to clinicians on how to best tailor these combination treatments to different pathogens, minimize the selection for resistance and formulate new antibiotic resistance inhibitors. Source: Duke University Pratt School of Engineering
Better MRI videos with new machine learning method

Better MRI videos with new machine learning method NIBIB in the News clehmann Tue, 10/08/2024 - 08:32
Using smartly trained neural networks, researchers at the University of Technology Graz funded in part by NIBIB have succeeded in generating precise real-time images of the beating heart from just a few MRI measurement data. Other MRI applications can also be accelerated using this procedure. Source: TU Graz News
Md. researcher’s insight into regenerating tissue leads to TIME innovator list

Md. researcher’s insight into regenerating tissue leads to TIME innovator list NIBIB in the News jgriffin Tue, 10/08/2024 - 12:26
Research into harnessing the immune system to encourage injured tissue to regenerate has landed a Maryland researcher on a TIME magazine list of 2024 innovators. During a WTOP visit to the lab she leads at the National Institute of Biomedical Imaging and Bioengineering, researcher Kaitlyn Sadtler, explained its goal is to understand the immune system’s role in wound healing and how it could be leveraged by medical technology to regenerate tissue.
Implementing medical imaging AI: issues to consider

Implementing medical imaging AI: issues to consider Science Highlights kolsen Tue, 10/01/2024 - 17:28
As AI is deployed in clinical centers across the U.S., one important consideration is to assure that models are fair and perform equally across patient groups and populations. To better understand the fairness of medical imaging AI, researchers trained over 3,000 models spanning multiple model configurations, algorithms, and clinical tasks. Their analysis of these models reinforced some previous findings about bias in AI algorithms and uncovered new insights about deployment of models in diverse settings.
New AI model efficiently reaches clinical-expert-level accuracy in complex medical scans

New AI model efficiently reaches clinical-expert-level accuracy in complex medical scans NIBIB in the News clehmann Tue, 10/01/2024 - 08:16
UCLA researchers have developed a deep-learning framework that teaches itself quickly to automatically analyze and diagnose MRIs and other 3D medical images – with accuracy matching that of medical specialists in a fraction of the time. Source: UCLA Computational Medicine News
Researchers reverse drug resistance in pancreatic cancer model

Researchers reverse drug resistance in pancreatic cancer model Science Highlights jgriffin Mon, 09/30/2024 - 11:15
Cancer cells frequently overhaul their surroundings, making tumors stiffer than nearby healthy tissue. While tumor stiffening makes some cancers easier to detect, it can also ramp up drug resistance. New research suggests that these detrimental changes are not set in stone, however.
Noninvasive method to monitor postprandial cardiovascular health

Noninvasive method to monitor postprandial cardiovascular health NIBIB in the News clehmann Thu, 09/26/2024 - 08:09
The dynamics of blood nutrient and lipid levels after consuming a high-fat meal are crucial indicators of both current and future cardiovascular health. A recent NIBIB-funded study from Boston University, Harvard Medical School, and Brigham and Women's Hospital investigated how meal composition affects skin tissue properties shortly after eating. Source: The International Society for Optics and Photonics News
Augmented reality navigation system could improve lumbar puncture accuracy

Augmented reality navigation system could improve lumbar puncture accuracy Science Highlights clehmann Tue, 09/17/2024 - 10:52
A team of researchers funded by a NIBIB Small Business program grant developed a new ultrasound navigation system that could provide accurate, real-time, and intuitive needle insertion planning and guidance for lumbar puncture procedures.
Building Better DNA Editors: Retrons Raise the Bar for Gene Research

Building Better DNA Editors: Retrons Raise the Bar for Gene Research NIBIB in the News clehmann Wed, 09/18/2024 - 08:30
Within bacterial cells, specialized immune systems known as retrons fend off viral attacks. They can also perform precise DNA editing.

In a new study published in Nature Biotechnology, Shipman and his team greatly expand the universe of retron knowledge. They carried out a “census” of 163 never-before-tested retrons and identified many that can edit DNA more quickly and efficiently than those currently used in research. This research may contribute to genome engineering and future gene therapies.
Blueprint MedTech continues to fuel the innovation of devices to treat and diagnose conditions affecting the nervous system

Blueprint MedTech continues to fuel the innovation of devices to treat and diagnose conditions affecting the nervous system Science Highlights raymond.macdougall Tue, 08/27/2024 - 13:00
NIH has just awarded $17 million for a group of projects undertaken by small and mid-sized businesses, nonprofit organizations, and academia participating in the Blueprint MedTech program.
Wearable lung patch uses deep learning to detect asthma and COPD

Wearable lung patch uses deep learning to detect asthma and COPD Science Highlights clehmann Wed, 09/11/2024 - 08:05
Early detection of respiratory diseases is critical for treatment. Researchers at the Georgia Institute of Technology have developed a wearable lung patch which, in a pilot study, detected wheezing, a common indicator of asthma and COPD.
New technology could lead to alternative treatments for antibiotic-resistant bacteria

New technology could lead to alternative treatments for antibiotic-resistant bacteria NIBIB in the News clehmann Fri, 09/06/2024 - 08:13
As antibiotic resistance becomes an increasingly serious threat to our health, the scientific and medical communities are searching for new medicines to fight infections. Researchers at Gladstone Institutes have just moved closer to that goal with a novel technique for harnessing the power of bacteriophages. Source: Gladstone Institutes News
Taking cues from nature, medical soft robots get smart

Taking cues from nature, medical soft robots get smart Science Highlights jgriffin Thu, 09/05/2024 - 10:15
Physical human feats require a high level of coordination between sensory and motor functions. What kind of achievements could robots perform with the same cohesion between sensing and action? In the medical space, researchers have begun to explore the possibilities.
Gene therapy gets a turbo boost from researchers

Gene therapy gets a turbo boost from researchers NIBIB in the News clehmann Tue, 09/03/2024 - 10:08
Gene therapy, the idea of fixing faulty genes with healthy ones, has held immense promise. But a major hurdle has been finding a safe and efficient way to deliver those genes.

Now, researchers at the University of Hawaiʻi’s John A. Burns School of Medicine (JABSOM) have made a significant breakthrough in gene editing technology that could revolutionize how genetic diseases are treated. Source: University of Hawaiʻi’s John A. Burns School of Medicine News
NIH prize challenge recognizes undergraduate biomedical engineers for innovative medical device designs

NIH prize challenge recognizes undergraduate biomedical engineers for innovative medical device designs Press Releases raymond.macdougall Tue, 08/20/2024 - 16:33
The National Institutes of Health and the higher education non-profit VentureWell have selected 11 winners and five honorable mentions in the Design by Biomedical Undergraduate Teams (DEBUT) Challenge, who are set to receive prizes totaling $160,000.